The small-molecule inhibitor of phosphoglycerate dehydrogenase. NCT-503. reduces incorporation of glucose-derived carbons into serine in vitro. Here we describe an off-target effect of NCT-503 in neuroblastoma cell lines expressing divergent phosphoglycerate dehydrogenase (PHGDH) levels and single-cell clones with CRISPR-Cas9-directed PHGDH knockout or their respective wildtype controls. https://chefesquipmenters.shop/product-category/accessories-table-parts/
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