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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

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Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however. the identification of causative mutations remains a limiting step. Current strategies depend on conventional mapping. so the propagation of affected mice requires non-lethal screens; accurate tracking of phenotypes through pe... https://www.roneverhart.com/Terry-s-Milk-Orange-Chocolate-with-Popping-Candy-12-Piece-Case/
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